|
KMID : 0616120170480040261
|
|
Korean Journal of Pharmacognosy
2017 Volume.48 No. 4 p.261 ~ p.267
|
|
|
Steroidal saponins from Dioscorea nipponica Rhizomes and Their Biological Activity
|
|
Park Kyoung-Jin
Suh Won-Se
Cha Joon-Min
Park Jong-Eel
Woo Kyeong-Wan
Kim Sun-Yeo
Lee Kang-Ro
|
|
|
Abstract
|
|
|
|
As part of the search for bioactive constituents of Korean medicinal plants, twelve steroids (1-12) were isolated from the rhizomes of Dioscorea nipponica. The isolated compounds were identified as diosgenin (3β, 25R)-spirost-5-en-3-ol (1), 25(R)-dracaenoside E (2), dioscin (3), gracillin (4), prosapogenin B (5), 25(R)-dracaenoside G (6), diosgenin 3-O-β-D-glucopyranosyl(1→3)-β-D-glucopyranoside (7), ophipogonin C′ (8), 7-oxodioscin (9), protodioscin (10), hypoglaucin F (11), and protoneogracillin (12). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. All the isolates (1-12) were evaluated for their neuroprotective effects through induction of nerve growth factor in C6 glioma cells and effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 7 and 12 were found to induce upregulation of NGF secretion without causing significant cell toxicity and compound 4 exhibited potent anti-neuroinflammatory activity.
|
|
|
KEYWORD
|
|
|
Dioscorea nipponica, Dioscoreaceae, Steroidal saponin, Neuroprotection, Anti-inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|